JAB: JAB1/Mov34/MPN/PAD-1 ubiquitin protease
| PAG Title | JAB: JAB1/Mov34/MPN/PAD-1 ubiquitin protease |
| PAG ID | PEX001172 |
| Type | A |
| Source Link |  Pfam |
| Publication Reference | NA |
| PAG Description | Members of this family are found in proteasome regulatory subunits, eukaryotic initiation factor 3 (eIF3) subunits and regulators of transcription factors. This family is also known as the MPN domain 3 and PAD-1-like domain 4, JABP1 domain 5 or JAMM domain 7. These are metalloenzymes that function as the ubiquitin isopeptidase/ deubiquitinase in the ubiquitin-based signalling and protein turnover pathways in eukaryotes 7. Versions of the domain in prokaryotic cognates of the ubiquitin-modification pathway are shown to have a similar role, and the archael protein from Haloferax volcanii is found to cleave ubiquitin-like small archaeal modifier proteins (SAMP1/2) from protein conjugates 8,9. |
| Species | Homo sapiens |
| nCoCo Score | 0 |
| Base PAG ID | PEX001172 |
| Human Phenotyte Annotation | |
| Curator | PAGER curation team |
| Curator Contact | PAGER-contact@googlegroups.com |
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